Genetic Evidence for High-Altitude Adaptation in Tibet

By T. Simonson, Yingzhong Yang, C. Huff, Haixia Yun, G. Qin, D. Witherspoon, Z. Bai, Felipe R Lorenzo, Jinchuan Xing, L. Jorde and 2 more. Science, 2010

1,146 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e67990f286b76e8e2a1a8df6ddb109c8f1a19a42

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

In Molecular Biology

Citations in the corpus

Robust Identification of Local Adaptation from Allele Frequencies (2012, background): “ison of closely related populations that dier strongly in environmental variables has already yielded many great candidate loci (see for example, altitude adaptation in Tibetans, Beall et al., 2010; Simonson et al., 2010; Yi et al., 2010). The methods developed here and elsewhere are part of realizi”
Prevalence and Ethnic Pattern of Diabetes and Prediabetes in China in 2013 (2017, background): “Variantsof 2genes involved inoxygenprocessingwere found inmostTibetanhighlanders,who thriveat altitudesgreater than4400m.(20)Significantvariation indietarypatternsamongdifferentethnicgroups alsohasbeen reported.”
Evolutionary origin of species diversity on the Qinghai–Tibet Plateau (2021, positive): “…sheep,” Canis familiaris “Tibetan dog,” Capra hircus “Tibetan goat,” Equus caballus “Tibetan horse” Wu et al. (2020); Liu et al. (2019); Li et al. (2018); Simonson et al. (2010) EGLN1, HIF1AN Homo saipiens “Tibetans” Simonson et al. (2010) C10orf67 Sus scrofa domesticus, Canis…”
Hypoxia-Inducible Factors in Physiology and Medicine (2012, background): “The basis for this remarkable evolutionary adaptation appears to have involved the selection of genetic variants at multiple loci encoding components of the oxygen-sensing system, particularly HIF-2a (Beall et al., 2010; Simonson et al., 2010; Yi et al., 2010).”
Demographic History and Genetic Adaptation in the Himalayan Region Inferred from Genome-Wide SNP Genotypes of 49 Populations (2018, background): “…1 and includes the 11th candidate SNP, rs6679627, an intronic variant in the Tripartite Motif Containing 67 (TRIM67) near Egl-9 family hypoxia inducible factor 1 (EGLN1), which has previously been associated with high-altitude adaptation in Tibetans (Simonson et al. 2010; Lorenzo et al. 2014).”
The yak genome and adaptation to life at high altitude (2012, background): “Notably, alleles of human ADAM17 were previously shown to be present at significant different frequencies in Tibetans and low-altitude dwellers 36 , indicating a possible role for this gene in altitude adaptation.”
ADAPTIVE AND MALADAPTIVE CARDIORESPIRATORY RESPONSES TO CONTINUOUS AND INTERMITTENT HYPOXIA MEDIATED BY HYPOXIA-INDUCIBLE FACTORS 1 AND 2 (2012, background): “(310) found a significant association of selected haplotypes at the EGLN1 and PPARA loci (which are HIF-1 target genes that encode prolyl hydroxylase PHD2 and peroxisome proliferator associated receptor- , respectively) with nonelevated hemoglobin phenotype that is unique to Tibetans.”