Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes

By C. Johnston, J. Moreno, J. Foreyt. Current Atherosclerosis Reports, 2014

1,534 citations recorded by the source corpus.

Look AHEAD (Action for Health in Diabetes) was a randomized controlled trial that examined the impact of long-term participation in an intensive weight loss intervention on cardiovascular disease (CVD) morbidity and mortality in people with type 2 diabetes (T2D). The results from this trial suggest that intensive lifestyle interventions are effective in helping patients to achieve management of cardiovascular risk factors and reducing the need to initiate medication usage to manage these conditions, though the benefits in terms of the prevention of CVD morbidity and mortality beyond those achieved through aggressive medical management of hypertension and dyslipidemia is not clear. Additional benefits of participation in an intensive lifestyle intervention such as lowered chronic kidney disease risk, blood pressure, medication usage, improved sleep apnea, and partial remission of diabetes are discussed.

Subfields: Endocrinology, Diabetes and Metabolism, Pharmacology

View Paper: https://www.semanticscholar.org/paper/e6585611e250714dac5e294ff0a809187b9b40bb

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In Endocrinology, Diabetes and Metabolism

In Pharmacology

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Citations in the corpus

Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) (2018, background): “In terms of intensive behavioural interventions, the Action for Health in Diabetes (Look AHEAD) trial [76] randomised 5145 overweight or obese patients with type 2 diabetes to an intensive lifestyle programme that promoted energy restriction, incorporating meal replacements to induce and sustain wei”
Update on the treatment of type 2 diabetes mellitus. (2016, background): “When this study was prolonged, it was found that intensive nutritional intervention did not provide an improvement in the rate of cardiovascular events or weight loss when it is compared against a standard nutritional intervention [26] .”
Eight-Year Weight Losses with an Intensive Lifestyle Intervention: The Look AHEAD Study (2014, neutral): “Participants A total of 5,145 men and women were enrolled in Look AHEAD at 16 centers throughout the United States (1,2).”
Maintenance of lost weight and long-term management of obesity (2018, background): “In the Look Ahead trial, 6% weight loss over 8 years yielded improvements in a range of cardiovascular risk factors, including glycemic control and lipids, as well as less medication usage, and reduced hospitalizations and health care costs.(87,88)”
Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. (2014, background): “among patients with DM and obesity would reduce risk for vascular events.(130,131) The Look AHEAD trial randomized”
2019 ESC/EAS guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk. (2019, background): “While the beneficial effects of weight reduction on metabolic and surrogate markers have been demonstrated, the benefits of weight loss on mortality and CV outcome are less clear.(175) Weight reduction can be achieved by decreasing the consumption of energy-dense foods, inducing a caloric deficit of”
Management of hyperglycaemia in type 2 diabetes, 2022. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) (2022, neutral): “none’ approach related to behavioural goals should be avoided as any improvement in healthy behaviours can have a positive impact in diabetes [93, 312].”
Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome. (2015, background): “These advances in the standard of care have increased the difficulty of showing incremental improvements in cardiovascular prognosis with intensification of glucose-lowering or lifestyle measures.(2,37) The few favorable demonstrations of reduced rates of cardiovascular events with predominantly glu”