Sphingolipids and their metabolism in physiology and disease

By Yusuf A. Hannun, LM Obeid. Nature reviews. Molecular cell biology, 2017

1,781 citations recorded by the source corpus.

Studies of bioactive lipids in general and sphingolipids in particular have intensified over the past several years, revealing an unprecedented and unanticipated complexity of the lipidome and its many functions, which rivals, if not exceeds, that of the genome or proteome. These results highlight critical roles for bioactive sphingolipids in most, if not all, major cell biological responses, including all major cell signalling pathways, and they link sphingolipid metabolism to key human diseases. Nevertheless, the fairly nascent field of bioactive sphingolipids still faces challenges in its biochemical and molecular underpinnings, including defining the molecular mechanisms of pathway and enzyme regulation, the study of lipid–protein interactions and the development of cellular probes, suitable biomarkers and therapeutic approaches.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e5d871ca1ea980008cedd60a216c25882ac11e88

Citations in the corpus

• Proteomic and Metabolomic Characterization of COVID-19 Patient Sera (2020, neutral): “Sphingolipids regulate diverse processes including growth regulation, cell migration, adhesion, apoptosis, senescence, and inflammatory responses (Hannun and Obeid, 2018).”