Gene regulation by long non-coding RNAs and its biological functions
By Luisa Statello, Chun-Jie Guo, Ling-Ling Chen, Maite Huarte. Nature reviews. Molecular cell biology, 2020
4,025 citations recorded by the source corpus.
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs) are widely expressed and have key roles in gene regulation. Recent studies have begun to unravel how the biogenesis of lncRNAs is distinct from that of mRNAs and is linked with their specific subcellular localizations and functions. Depending on their localization and their specific interactions with DNA, RNA and proteins, lncRNAs can modulate chromatin function, regulate the assembly and function of membraneless nuclear bodies, alter the stability and translation of cytoplasmic mRNAs and interfere with signalling pathways. Many of these functions ultimately affect gene expression in diverse biological and physiopathological contexts, such as in neuronal disorders, immune responses and cancer. Tissue-specific and condition-specific expression patterns suggest that lncRNAs are potential biomarkers and provide a rationale to target them clinically. In this Review, we discuss the mechanisms of lncRNA biogenesis, localization and functions in transcriptional, post-transcriptional and other modes of gene regulation, and their potential therapeutic applications. Recent studies have provided novel insight into the biogenesis of long non-coding RNAs (lncRNAs) and their specific functions. The functions of lncRNAs vary from transcriptional and post-transcriptional gene regulation to the assembly and function of membraneless nuclear bodies, and are relevant to neuronal disorders, immune responses and cancer.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/e5c74204a15eb2ad27a98b160405e001d809bbef
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
- George A. Calin
- M. Ferracin
- Kinga Nemeth
- R. Bayraktar
- M. Guttman
- Carlo Maria Croce
- Joshua T. Mendell
- Ling-Ling Chen
In Molecular Biology
Citations in the corpus
- Recent advances in RNA structurome (2022, background): “conformations to control transcription, RNA splicing, RNA stability and mRNA translation (Statello et al., 2021).”
- Xist nucleates local protein gradients to propagate silencing across the X chromosome (2021, background): “Mammalian genomes encode thousands of long non-coding (lnc) RNAs, many of which play key roles in regulating gene expression by localizing effector proteins to genomic targets (Engreitz et al., 2016; Rinn and Chang, 2012; Statello et al., 2021).”
- Non-coding RNAs in disease: from mechanisms to therapeutics (2023, positive): “…reflected in their function, which includes genomic, transcriptional and translational regulation of neighbouring and distant genes 24,52–54 . lncRNAs can directly interact with DNA, forming R-loops 55 , and can associate with enhancers or promoters, activating or suppressing their function 56–59 .”