Epidemiology and Diagnostics of Carbapenem Resistance in Gram-negative Bacteria

By P. Nordmann, L. Poirel. Clinical Infectious Diseases, 2019

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Abstract Carbapenem resistance in gram-negative bacteria has caused a global epidemic that continues to grow. Although carbapenemase-producing Enterobacteriaceae have received the most attention because resistance was first reported in these pathogens in the early 1990s, there is increased awareness of the impact of carbapenem-resistant nonfermenting gram-negative bacteria, such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia. Moreover, evaluating the problem of carbapenem resistance requires the consideration of both carbapenemase-producing bacteria as well as bacteria with other carbapenem resistance mechanisms. Advances in rapid diagnostic tests to improve the detection of carbapenem resistance and the use of large, population-based datasets to capture a greater proportion of carbapenem-resistant organisms can help us gain a better understanding of this urgent threat and enable physicians to select the most appropriate antibiotics.

Subfields: Clinical Biochemistry, Endocrinology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/e52d58d226f1a1b6464c57e0dbca4232e1b19fba