A sperm ion channel required for sperm motility and male fertility

By Dejian Ren, B. Navarro, G. Perez, A. C. Jackson, Shyuefang Hsu, Qing Shi, Jonathan L. Tilly, D. Clapham. Nature, 2001

897 citations recorded by the source corpus.

Subfields: Molecular Biology, Public Health, Environmental and Occupational Health, Reproductive Medicine

View Paper: https://www.semanticscholar.org/paper/687ebaf82514030f5033c8efd4ae0d2db136a131

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Vladimir N Uversky
2. A. Keith Dunker
3. Christopher J. Oldfield
4. Lukasz Kurgan
5. Zsuzsanna Dosztányi
6. Michael Sanguinetti
7. M. Matzuk
8. Bálint Mészáros

In Public Health, Environmental and Occupational Health

1. M. Matzuk
2. Organización Mundial de la Salud
3. Eric Lauga

In Reproductive Medicine

1. M. Matzuk
2. Eric Lauga

Citations in the corpus

• The biology of infertility: research advances and clinical challenges (2008, background): “Targeted deletion of any of these four genes in the mouse leads to male infertility or immotile sperm with no other apparent phenotypic differenc”
• Cyclic nucleotide-gated ion channels. (2002, background): “Mouse sperm express two other channels (CatSper1 and CatSper2) that bear similarity with a single repeat of the four-repeat structure of voltage-activated Ca(2) channels (332, 336).”
• Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. (2004, background): “…Brini and Carafoli, Igor Splawski,1,* Katherine W. Timothy,2 Leah M. Sharpe,1 Niels Decher,3 Pradeep Kumar,3 Raffaella Bloise,4 Carlo Napolitano,4 Peter J. Schwartz,5,6 Robert M. Joseph,7 Karen Condouris,7 Helen Tager-Flusberg,7 Silvia G. Priori,4,5 Michael C. Sanguinetti,3 2000; Ren et al., 2001).”
• Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling (2005, background): “CATSPER1 is a voltage-gated Ca2þ channel, which is exclusively found in the plasma membrane of the principal piece of the sperm tail, being necessary for the cAMP-induced Ca2þ influx, normal sperm motility and penetration of the egg (Ren et al., 2001).”
• Advances in male contraception. (2008, background): “One approach to blocking sperm motility—and sperm hyperactivation in particular—has focused on a group of four novel sperm-specific transmembrane proteins termed “CatSpers” (354).”
• Sperm transport in the female reproductive tract. (2006, background): “Although they show normal vigorous progressive motility, they cannot hyperactivate and do not penetrate artificial mucus as well as wild-type sperm (Quill et al., 2001, 2003; Ren et al., 2001; Carlson et al., 2003).”