Colony-stimulating factor-1 in immunity and inflammation.

By V. Chitu, E. Stanley. Current Opinion in Immunology, 2006

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Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. (2014, background): “Colony-stimulating factor 1 (CSF-1) and its receptor, CSF-1R, regulate the migration, differentiation, and survival of macrophages and their precursors (Hume and MacDonald 2012; Chitu and Stanley 2006).”
TREM2 lipid sensing sustains microglia response in an Alzheimer’s disease model (2015, neutral): “Previous studies have shown that CSF-1-CSF-1R signaling is essential for microgliosis in response to Aβ (Chitu and Stanley, 2006; Kaku et al., 2003; Mitrasinovic et al., 2003).”
Gamma frequency entrainment attenuates amyloid load and modifies microglia (2016, positive): “The upregulated genes were positively correlated with gene expression changes induced by macrophage colony-stimulating factor and granulocyte macrophage colony-stimulating factor, known to promote microglial A β uptake 21 (Extended Data Fig.”
From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation (2014, background): “CSF-1 is constitutively produced by mesenchymal cells (105) and is detectable in circulation in resting conditions (20).”