Extracellular-matrix tethering regulates stem-cell fate.

By B. Trappmann, J. Gautrot, J. Connelly, D. G. Strange, Yuan Li, M. Oyen, M. C. Cohen Stuart, Heike Boehm, Bojun Li, Viola Vogel and 3 more. Nature Materials, 2012

1,488 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology

View Paper: https://www.semanticscholar.org/paper/3a187c3c421d9ee0f471d6c85254011d9eae13be

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Citations in the corpus

Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity (2021, background): “Currently, the investigations on the two hydrogels have been fully carried out, and they were found to play an important role in drug delivery, mesenchymal stem cell (MSC) carrier, and other tissue engineering.(99,100) However, the poor biodegradability and potential toxic effect of such two hydroge”
Physics of adherent cells (2013, background): “In addition, recent experiments have shown that differentiation may also depend on the mechanics of the ligand molecule and not only on the bulk rigidity of the substrate (Trappmann et al., 2012).”
Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation (2013, background): “matrix elasticity in two-dimensional (2D) (7) or 3D cultures (8), several other studies have found that”
Integrin-mediated mechanotransduction (2016, background): “Indeed, the spreading and osteoblast differentiation of human mesenchymal stem cells (hMSCs) are inhibited on soft polyacrylamide hydrogel, but not on soft polydimethylsiloxane, a highly viscous material (Trappmann et al., 2012).”