HMDB 5.0: the Human Metabolome Database for 2022
By David S. Wishart, Anchi Guo, Eponine Oler, Fei Wang, Afia Anjum, Harrison Peters, Raynard Dizon, Zinat Sayeeda, Siyang Tian, Brian L. Lee and 27 more. 2021
638 citations recorded by the source corpus.
Abstract The Human Metabolome Database or HMDB (https://hmdb.ca) has been providing comprehensive reference information about human metabolites and their associated biological, physiological and chemical properties since 2007. Over the past 15 years, the HMDB has grown and evolved significantly to meet the needs of the metabolomics community and respond to continuing changes in internet and computing technology. This year's update, HMDB 5.0, brings a number of important improvements and upgrades to the database. These should make the HMDB more useful and more appealing to a larger cross-section of users. In particular, these improvements include: (i) a significant increase in the number of metabolite entries (from 114 100 to 217 920 compounds); (ii) enhancements to the quality and depth of metabolite descriptions; (iii) the addition of new structure, spectral and pathway visualization tools; (iv) the inclusion of many new and much more accurately predicted spectral data sets, including predicted NMR spectra, more accurately predicted MS spectra, predicted retention indices and predicted collision cross section data and (v) enhancements to the HMDB’s search functions to facilitate better compound identification. Many other minor improvements and updates to the content, the interface, and general performance of the HMDB website have also been made. Overall, we believe these upgrades and updates should greatly enhance the HMDB’s ease of use and its potential applications not only in human metabolomics but also in exposomics, lipidomics, nutritional science, biochemistry and clinical chemistry.
Subfields: Computational Theory and Mathematics, Molecular Biology
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- Shi Qiu
- Craig Knox
- Songqi Tang
- Eponine Oler
- Afia Anjum
- Mark N. Franklin
- A. Wilson
- Ying Cai
Citations in the corpus
- Small molecule metabolites: discovery of biomarkers and therapeutic targets (2023, background): “0 database.(106) Number of small metabolites was identified in urine and blood are 5661 and 38,036, respectively.”
- DrugBank 6.0: the DrugBank Knowledgebase for 2024 (2023, background): “The biotech drugs can be further broken down into allergenics [numbering 51], gene therapies [21], cell transplant therapies [11], protein-based therapies [89] and vaccines [249].”