Empirical correlation between hydrophobic free energy and aqueous cavity surface area.

By J. Reynolds, D. B. Gilbert, Charles Tanford. 1974

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Five computational developability guidelines for therapeutic antibody profiling (2019, methodology): “As the energy of the hydrophobic effect is approximately proportional to the interface area (30), we developed a metric, PSH (Methods), that yields higher scores if hydrophobic residues tend to neighbor one another in a region, rather than being evenly separated.”
In silico prediction of aqueous solubility (2006, background): “It is not surprising that more work has been published on solubility–molecular surface area correlations than on solubility–molecular volume correlations, as it is the surface area of a solute molecule that touches and interacts with the water molecules surrounding it [52].”