Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts.

By R. Brugada, J. Brugada, C. Antzelevitch, G. Kirsch, D. Potenza, J. Towbin, P. Brugada. Circulation, 2000

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ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (2006, background): “ST-segment elevation can occur spontaneously or be exposed by administration of sodium channel blockers such as flecainide, procainamide, or ajmaline.(825) There is agreement that patients with a spontaneous pattern have a worse prognosis than individuals in whom the typical ECG is observed only aft”