Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses

By A. Okbay, B. Baselmans, J. De Neve, P. Turley, M. Nivard, M. Fontana, S. Meddens, R. Linnér, C. A. Rietveld, J. Derringer and 177 more. Nature Genetics, 2016

986 citations recorded by the source corpus.

Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

Subfields: Experimental and Cognitive Psychology, Genetics, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/e3e819b6d88696aac80a64623435df2b34d82b3e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Experimental and Cognitive Psychology

In Genetics

In Pediatrics, Perinatology and Child Health

Citations in the corpus

Bayesian weighted Mendelian randomization for causal inference based on summary statistics (2018, background): “…al., 2017) Social Trait SW depressive symptoms 161,460 (Okbay et al., 2016) Category Name # Sample Size Reference Social Trait SW neuroticism 170,911 (Okbay et al., 2016) Social Trait SW subjective well being 298,420 (Okbay et al., 2016) Social Trait TAG age onset 47,961 (Furberg et al., 2010)…”
Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes (2018, background): “Intronic SNPs inCSE1L have been associated with subjective well-being (Okbay et al., 2016) and nominally to antidepressant response (Li et al., 2016).”
Comparative genetic architectures of schizophrenia in East Asian and European populations (2018, neutral): “Traits tested included schizophrenia 2 , bipolar 68 , major depression 69 , anorexia nervosa 70 , neuroticism & subjective well-being (SWB) 71 , autism spectrum disorder (PGC 2015 release, available at http://www.med.unc.edu/pgc), attention deficit hyperactivity disorder (with samples of…”
The genetic architecture of the human cerebral cortex (2020, background): “For total SA, significant negative genetic correlationswere detectedwith insomnia (55), attention deficit hyperactivity disorder (ADHD) (56), depressive symptoms (57), major depressive disorder (58), and neuroticism (29) (Fig.”