Solid supported lipid bilayers: From biophysical studies to sensor design
By Edward T. Castellana, P. Cremer. Surface science reports, 2006
1,056 citations recorded by the source corpus.
The lipid bilayer is one of the most eloquent and important self-assembled structures in nature. It not only provides a protective container for cells and sub-cellular compartments, but also hosts much of the machinery for cellular communication and transport across the cell membrane. Solid supported lipid bilayers provide an excellent model system for studying the surface chemistry of the cell. Moreover, they are accessible to a wide variety of surface-specific analytical techniques. This makes it possible to investigate processes such as cell signaling, ligand–receptor interactions, enzymatic reactions occurring at the cell surface, as well as pathogen attack. In this review, the following membrane systems are discussed: black lipid membranes, solid supported lipid bilayers, hybrid lipid bilayers, and polymer cushioned lipid bilayers. Examples of how supported lipid membrane technology is interfaced with array based systems by photolithographic patterning, spatial addressing, microcontact printing, and microfluidic patterning are explored. Also, the use of supported lipid bilayers in microfluidic devices for the development of lab-on-a-chip based platforms is examined. Finally, the utility of lipid bilayers in nanotechnology and future directions in this area are discussed.
Subfields: Biomedical Engineering, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/e39b5610632d0fb822d69d1e0d28ff6db14efdaa
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In Biomedical Engineering
- Robert MacKenzie
- Wolfgang Knoll
- Jie He
- János Vörös
- D. Grieshaber
- Erik Reimhult
- Laura Sagle
- Sarah Unser
In Molecular Biology
Citations in the corpus
- Biotechnology Applications of Tethered Lipid Bilayer Membranes (2012, background): “Several excellent references are available that provide a comprehensive overview of solid-supported model membrane systems, including their design and characterization [9].”
- Localized Surface Plasmon Resonance Biosensing: Current Challenges and Approaches (2015, background): “formed on hydrophilic supports (supported lipid bilayers) are a well-characterized model membrane system that can be prepared to mimic different cellular membrane environments [108].”
- Electrochemical Biosensors - Sensor Principles and Architectures (2008, methodology): “The membranes can be directly adsorbed or tethered to the surface, but also separated from the sensor substrate by a hydrogel [265, 266, 267].”
- Substrate Effects on the Formation Process, Structure and Physicochemical Properties of Supported Lipid Bilayers (2012, neutral): “In addition, surface patterning and machining techniques can be applied to the area-selective SLB formation and manipulation of molecules in SLBs [19–32].”