Hematological findings and complications of COVID‐19

By E. Terpos, I. Ntanasis-Stathopoulos, I. Elalamy, E. Kastritis, T. Sergentanis, M. Politou, T. Psaltopoulou, G. Gerotziafas, M. Dimopoulos. American journal of hematology/oncology, 2020

1,612 citations recorded by the source corpus.

COVID‐19 is a systemic infection with a significant impact on the hematopoietic system and hemostasis. Lymphopenia may be considered as a cardinal laboratory finding, with prognostic potential. Neutrophil/lymphocyte ratio and peak platelet/lymphocyte ratio may also have prognostic value in determining severe cases. During the disease course, longitudinal evaluation of lymphocyte count dynamics and inflammatory indices, including LDH, CRP and IL‐6 may help to identify cases with dismal prognosis and prompt intervention in order to improve outcomes. Biomarkers, such high serum procalcitonin and ferritin have also emerged as poor prognostic factors. Furthermore, blood hypercoagulability is common among hospitalized COVID‐19 patients. Elevated D‐Dimer levels are consistently reported, whereas their gradual increase during disease course is particularly associated with disease worsening. Other coagulation abnormalities such as PT and aPTT prolongation, fibrin degradation products increase, with severe thrombocytopenia lead to life‐threatening disseminated intravascular coagulation (DIC), which necessitates continuous vigilance and prompt intervention. So, COVID‐19 infected patients, whether hospitalized or ambulatory, are at high risk for venous thromboembolism, and an early and prolonged pharmacological thromboprophylaxis with low molecular weight heparin is highly recommended. Last but not least, the need for assuring blood donations during the pandemic is also highlighted.

Subfields: Dermatology, Infectious Diseases, Oncology

View Paper: https://www.semanticscholar.org/paper/e394f2dd688ee60cff01000194e89c8ba495bbe0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. G. Keser
2. F. Tabak
3. S. Kayhan
4. I. Atagündüz
5. P. Atagündüz
6. M. Soy

Citations in the corpus

• Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment (2020, background): “Generally, the number of CD8 T lymphocytes recovers in 2-3 months, whereas it may take nearly a year for the memory CD4 T lymphocytes to recover in SARS CoV infection [9-13].”