Mouse Estrous Cycle Identification Tool and Images
By Shannon Byers, M. Wiles, Sadie L. Dunn, R. Taft. PLoS ONE, 2012
1,072 citations recorded by the source corpus.
The efficiency of producing timed pregnant or pseudopregnant mice can be increased by identifying those in proestrus or estrus. Visual observation of the vagina is the quickest method, requires no special equipment, and is best used when only proestrus or estrus stages need to be identified. Strain to strain differences, especially in coat color can make it difficult to determine the stage of the estrous cycle accurately by visual observation. Presented here are a series of images of the vaginal opening at each stage of the estrous cycle for 3 mouse strains of different coat colors: black (C57BL/6J), agouti (CByB6F1/J) and albino (BALB/cByJ). When all 4 stages (proestrus, estrus, metestrus, and diestrus) need to be identified, vaginal cytology is regarded as the most accurate method. An identification tool is presented to aid the user in determining the stage of estrous when using vaginal cytology. These images and descriptions are an excellent resource for learning how to determine the stage of the estrous cycle by visual observation or vaginal cytology.
Subfields: Agronomy and Crop Science, Small Animals
View Paper: https://www.semanticscholar.org/paper/e37fc84f4b9248632aed77ff3a1fbedf7a9ab785
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In Small Animals
Citations in the corpus
- Vaginal cytology of the laboratory rat and mouse – review and criteria for the staging of the estrous cycle using stained vaginal smears (2015, methodology): “Multiple references regarding the cytology of the rat and mouse estrous cycle are available (Allen 1922; Byers et al. 2012; Caligioni 2009; Cooper and Goldman 1999; Goldman, Murr, and Cooper 2007; Hubscher, Brooks, and Johnson 2005; Long and Evans 1922; Mandl 1951; Organization for Economic…”