Autophagy in major human diseases

By D. Klionsky, G. Petroni, R. Amaravadi, Eric H. Baehrecke, Andrea Ballabio, P. Boya, J. M. Bravo-San Pedro, K. Cadwell, F. Cecconi, A. Choi and 49 more. EMBO Journal, 2021

1,344 citations recorded by the source corpus.

Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy‐related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.

Subfields: Epidemiology, Neurology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/e361a5681c49c1247b63f509c143330232770018

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Citations in the corpus

• Targeting p53 pathways: mechanisms, structures and advances in therapy (2023, background): “166,167 p53 can directly activate damage-regulated autophagy regulators and induce autophagy.”