Mechanobiology and diseases of mechanotransduction

By Donald E. Ingber. Annals medicus, 2003

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Review on Cell Mechanics: Experimental and Modeling Approaches (2013, background): “If a cell misinterprets a mechanical cue or finds itself within an abnormal environment, its normal function can be disrupted and disease states can arise [4].”
Three-dimensional bioprinting of thick vascularized tissues (2016, background): “T ability to manufacture human tissues that replicate the essential spatial (1), mechanochemical (2, 3), and temporal aspects of biological tissues (4) would enable myriad applications, including 3D cell culture (5), drug screening (6, 7), disease modeling (8), and tissue repair and regeneration (9,”
Physics of adherent cells (2013, background): “Cells in tissues respond to a variety of mechanical forces that influence their behavior and alignment such as gravity, muscle tension, blood pressure as well as from local active tractions of nearby cells (Chen, 2008; Ingber, 2003).”
Mechanics, malignancy, and metastasis: The force journey of a tumor cell (2009, background): “These forces can originate from neighboring cells or the ECM and are channeled through specific adhesion receptors [10], as well as through mechanical loads applied nonspecifically to the entire tissue, including interstitial forces and shear flows [11].”