Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration
By Liang Ma, Y. Li, Junya Peng, Danni Wu, Xiaoxin Zhao, Yitong Cui, Lilian Chen, Xiaojun Yan, Yanan Du, Li Yu. Cell Research, 2014
598 citations recorded by the source corpus.
Cells communicate with each other through secreting and releasing proteins and vesicles. Many cells can migrate. In this study, we report the discovery of migracytosis, a cell migration-dependent mechanism for releasing cellular contents, and migrasomes, the vesicular structures that mediate migracytosis. As migrating cells move, they leave long tubular strands, called retraction fibers, behind them. Large vesicles, which contain numerous smaller vesicles, grow on the tips and intersections of retraction fibers. These fibers, which connect the vesicles with the main cell body, eventually break, and the vesicles are released into the extracellular space or directly taken up by surrounding cells. Since the formation of these vesicles is migration-dependent, we named them “migrasomes”. We also found that cytosolic contents can be transported into migrasomes and released from the cell through migrasomes. We named this migration-dependent release mechanism “migracytosis”.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/e32bd5a806e9a9871382741732ce2d413ae60a0a
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Citations in the corpus
- Challenges and directions in studying cell–cell communication by extracellular vesicles (2022, background): “Ectosomes are either released from tips of membrane extensions such as filipodia [G] or microvilli [G] or by retraction and scission from nanotubes [G] and retraction firers such as in the case of migrasomes 23 .”
- Exosomes in cancer development, metastasis, and immunity (2019, background): “As cells migrate, the migrasomes are released into the extracellular environment and are taken up by surrounding cells, but the exact function of the migrasomes in the recipient cells is unclear [12].”