Mechanisms of Leukocyte Transendothelial Migration
By Werner Müller. Annual Review of Pathology, 2011
616 citations recorded by the source corpus.
Neither the innate nor adaptive immune system “responds” unless leukocytes cross blood vessels. This process occurs through diapedesis, in which the leukocyte moves in an ameboid fashion through tightly apposed endothelial borders and, in some cases, through the endothelial cell itself. This review focuses on the active role of the endothelial cell in diapedesis. Several mechanisms play a critical role in transendothelial migration, including signals derived from clustering of apically disposed intercellular adhesion molecule 1 and vascular cell adhesion molecule 1, disruption or loosening of adherens junctions, and targeted recycling of platelet/endothelial cell adhesion molecule and other molecules from the recently described lateral border recycling compartment. Surprisingly, many of the same molecules and mechanisms that regulate paracellular migration also control transcellular migration. A hypothesis that integrates the various known mechanisms of transmigration is proposed.
Subfields: Immunology, Immunology and Allergy, Neurology
View Paper: https://www.semanticscholar.org/paper/e325ad8f94cd50542773019d6593e42ea882eea5
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Citations in the corpus
- DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation. (2020, background): “, the paracellular route, 80–90%), with transcellular migration being relatively rare (48).”
- Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions. (2013, background): “endothelial cells (Engelhardt and Wolburg, 2004; Muller, 2011; Wolburg et al., 2005).”