Integrated optical devices for lab‐on‐a‐chip biosensing applications

By M. Estévez, Mar Alvarez, Laura M. Lechuga. 2012

565 citations recorded by the source corpus.

The application of portable, easy‐to‐use and highly sensitive lab‐on‐a‐chip biosensing devices for real‐time diagnosis could offer significant advantages over current analytical methods. Integrated optics‐based biosensors have become the most suitable technology for lab‐on‐chip integration due to their ability for miniaturization, their extreme sensitivity, robustness, reliability, and their potential for multiplexing and mass production at low cost. This review provides an extended overview of the state‐of‐the‐art in integrated photonic biosensors technology including interferometers, grating couplers, microring resonators, photonic crystals and other novel nanophotonic transducers. Particular emphasis has been placed on describing their real biosensing applications and wherever possible a comparison of the sensing performances between each type of device is included. The way towards achieving operative lab‐on‐a‐chip platform incorporating the photonic biosensors is also reviewed. Concluding remarks regarding the future prospects and potential impact of this technology are also provided.

Subfields: Atomic and Molecular Physics, and Optics, Bioengineering, Electrical and Electronic Engineering

View Paper: https://www.semanticscholar.org/paper/e31575bb8663b879cd97e6b897257f1ae8bc87c2

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In Atomic and Molecular Physics, and Optics

In Bioengineering

In Electrical and Electronic Engineering

Citations in the corpus

Silicon Photonic Biosensors Using Label-Free Detection (2018, background): “Also, slot-waveguide based structures are 282 also CMOS compatible which enables miniaturization and integration for a lab-on-a-chip platform with low 283 cost [38,125].”
Ultra‐broadband nanophotonic beamsplitter using an anisotropic sub‐wavelength metamaterial (2016, background): “Integrated photonic systems are poised to produce key advances in areas such as optical communications [1,2], sensing [3, 4], spectroscopy [5, 6], metrology [7], frequency comb generation [8] and quantum physics [9, 10].”
Photonic crystal resonances for sensing and imaging (2018, background): “As briefly mentioned above, interferometric sensors show the highest sensitivities and the lowest limits of detection ever reported [111].”