From discoveries in ageing research to therapeutics for healthy ageing

By J. Campisi, P. Kapahi, G. Lithgow, S. Melov, John C. Newman, E. Verdin. Nature, 2019

1,090 citations recorded by the source corpus.

For several decades, understanding ageing and the processes that limit lifespan have challenged biologists. Thirty years ago, the biology of ageing gained unprecedented scientific credibility through the identification of gene variants that extend the lifespan of multicellular model organisms. Here we summarize the milestones that mark this scientific triumph, discuss different ageing pathways and processes, and suggest that ageing research is entering a new era that has unique medical, commercial and societal implications. We argue that this era marks an inflection point, not only in ageing research but also for all biological research that affects the human healthspan. The milestones that mark the advances in ageing research, the medical, commercial and societal implications of ageing and the different ageing pathways and processes that are associated with ageing are discussed.

Subfields: Aging, Health, Toxicology and Mutagenesis, Physiology

View Paper: https://www.semanticscholar.org/paper/e2de9322aad22d093732697894295cd440122bcd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. Steve Horvath
2. H. Harrington
3. D. Kwon
4. David L. Corcoran
5. Benjamin S. Williams
6. Renate M. Houts
7. Richie Poulton
8. Karen Sugden

In Health, Toxicology and Mutagenesis

1. Carol Worthman
2. J. Belsky
3. Julia Kim-Cohen
4. E. Nestler
5. Andrea L. Gold
6. V. Krishnan
7. Benjamin B. Lahey

In Physiology

1. Andrea A. Baccarelli
2. D. Kwon
3. Daniel W Belsky
4. Steve Horvath
5. Manolis Kellis
6. Jason Ernst

Citations in the corpus

• DNA methylation aging clocks: challenges and recommendations (2019, background): “This aim of maximizing the “healthspan” [2] makes obtaining accurate measures of aging-related pathology essential, to gauge its speed, decipher the changes that occur, and potentially unlock how aging acts as a disease risk factor [4].”
• Inflammation and aging: signaling pathways and intervention therapies (2023, background): “Later, inflammaging has been considered a hallmark of aging.(3) Meanwhile, it is worth mentioning that can also damage the immune system, leading to immunosenescence during aging.”
• A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge (2021, background): “Experiments with animals show these processes can be modified, extending healthy lifespan for worms, flies, and mice [4, 5].”
• DunedinPACE, a DNA methylation biomarker of the pace of aging (2021, methodology): “Guided by research on the cellular hallmarks of aging, model-organism studies are yielding treatments that slow the accumulation of deterioration in cells and organs (Barzilai et al., 2018; Bellantuono, 2018; Campisi et al., 2019).”