Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances.

By S. Hwang, Hawon Cho, Jiyeon Kwak, Soon-Youl Lee, Chang-Joong Kang, Jooyoung Jung, S. Cho, K. Min, Y. Suh, Dong Hee Kim and 1 more. Proceedings of the National Academy of Sciences of the United States of America, 2000

1,075 citations recorded by the source corpus.

Subfields: Molecular Biology, Nutrition and Dietetics, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/e29093b423735e78713fd0f9e49c103ad97e302c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. D. Julius
2. M. Caterina

In Nutrition and Dietetics

1. M. Caterina
2. D. Julius
3. S. R. Eid

In Sensory Systems

1. D. Julius
2. M. Caterina
3. S. R. Eid
4. Clifford J. Woolf
5. Ardem Patapoutian
6. Yifan Cheng
7. Arne May

Citations in the corpus

• The vanilloid receptor: a molecular gateway to the pain pathway. (2001, background): “…bioactive substances reidentified anandamide as an activator of VR1 (Smart et al 2000), and a directed analysis of arachidonic acid metabolites identified lipooxygenase products [e.g. 12- or 15-(S)-Hydroperoxyeicosa-5Z, 8Z, 11Z, 13E-tetraenoic acid] as agonists of this channel (Hwang et al 2000).”
• The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept (2007, background): “; lipoxygenase products (12-hydroperoxyeicosatetraenoic acid (12-HPETE) and 15-HPETE”
• Cannabinoid receptors and their ligands. (2002, neutral): “199 It is possible that analogous anandamide lipoxygenase metabolites may have vanilloid receptor activity.”