ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation.

By Kazuaki Umeda, Junichi Ikenouchi, S. Katahira-Tayama, Kyoko Furuse, H. Sasaki, Mayumi Nakayama, T. Matsui, Sachiko Tsukita, M. Furuse, S. Tsukita. Cell, 2006

845 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/e27e56a6dacdb9cb96310468929d46f71da60914

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In Molecular Biology

1. C. Niessen
2. Andrea Hartsock
3. Gerd Krause
4. J. Turner
5. B. Barres
6. W. Nelson
7. P. Cossart
8. S. Mostowy

In Neurology

1. B. Barres
2. J. Turner
3. D. Agalliu
4. C. Niessen
5. A. Nimmerjahn
6. M. Sofroniew
7. P. Cossart
8. S. Mostowy

Citations in the corpus

• Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation (2012, neutral): “It is well established that ZO proteins are essential to the assembly of claudins [60], occludin [35] and JAM-A [61] at TJs, then anchoring this multimolecular complex to”
• Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke (2014, positive): “In addition, many eGFP+ TJs strands in venules (22%), but not capillaries, had multiple protrusions at 48–58 h post-t-MCAO (Figure 2J, K, N, O) and an aberrant zigzag appearance (Figure 2L) reminiscent of ZO-1/2-deficient epithelial cells (Umeda et al., 2006).”
• Structure and function of claudins. (2008, background): “The scaffolding proteins zonula occludens (ZO)-1 and -2 are essential for the spatial organisation of claudin-based membranous strands in epithelial cells [21], but not for basic strand formation in claudin-transfected unpolar cells [22].”
• Tight Junction Pore and Leak Pathways: A Dynamic Duo (2011, background): “TAMPs: tight junction–associated marvel proteins bind to C-terminal YV motifs of most claudins (67) and are necessary for efficient junctional claudin delivery (65, 68, 69).”
• Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. (2008, background): “In addition, in a ZO-1 knock-out/ZO-2 knock-down cell line, exogenous expression of either ZO-1 or ZO-2 alone could restore claudin localization to tight junctions as seen by immunofluorescence [115].”
• Tight junctions/adherens junctions: basic structure and function. (2007, background): “Vice versa, loss of ZO1/ZO-2 did result in a more lateral distribution of Par3 but without obvious loss of apico-basolat-eral polarity (Umeda et al ., 2006).”
• Epithelial barriers in homeostasis and disease. (2010, background): “Although the mechanisms that direct ZO-1 to the nascent tight junction require further investigation, it is clear that poorly characterized carboxy-terminal regions of ZO-1 are required (14, 15) and that ZO-1 initially interacts with alpha-catenin at sites of cell-cell contact before separating from”