Human Hypertension Caused by Mutations in WNK Kinases
By F. H. Wilson, S. Disse-Nicodème, K. Choate, K. Ishikawa, C. Nelson-Williams, Isabelle Desitter, M. Gunel, D. Milford, G. Lipkin, J. Achard and 9 more. Science, 2001
1,431 citations recorded by the source corpus.
Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Nutrition and Dietetics
View Paper: https://www.semanticscholar.org/paper/e25d287606694a6a128756ee6fb58f8c233c4863
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In Endocrinology, Diabetes and Metabolism
In Molecular Biology
In Nutrition and Dietetics
Citations in the corpus
- Inwardly rectifying potassium channels: their structure, function, and physiological roles. (2010, background): “Mutations in either of the WNK1 or WNK4 genes are associated with pseudo-hypoaldosteronism type II (PHAII: also referred to as Gordon’s syndrome) which exhibits hypertension with hyperkalemia in an autosomal dominant form (841).”
- Mutations in Kelch-like 3 and Cullin 3 cause hypertension and electrolyte abnormalities (2012, background): “The wild-type construct produces complementary DNA with properly spliced junctions between exons 8–9 (top) and 9–10 (middle), whereas the mutant construct (splice donor g(11)c) produces cDNA joining exon 8 to exon 10 (bottom).”
- Mendelian Inheritance in Man and Its Online Version, OMIM (2007, neutral): “Some have rare Mendelian subtypes that represent no problem for entry in OMIM: Lifton and his colleagues 61,62 tabulated eight rare Mendelian forms of hypertension, each due to a disturbance in the handling of sodium by the renal tubules.”
- Crosstalk of tight junction components with signaling pathways. (2008, neutral): “MDCK ZO-2 [39] ζ MDCK, Caco-2 ZO-1 [40,41] MDCK ZO-2 [39] ζ T-84 Occludin [42] CK Iε HUVEC Occludin [260] ERK1 Caco-2 Occludin [160] WNK4 Distal nephron [229] c-Yes MDCK, T-84 Occludin [269,42] PI3K T-84, Caco-2 Occludin [42,209] Con8 ZO-1 [162] PP2A MDCK ZO-1, occludin, claudin-1 [125]”
- Links between dietary salt intake, renal salt handling, blood pressure, and cardiovascular diseases. (2005, background): “Activating mutations in two isoforms of the WNK kinase family (WNK1 and WNK4) expressed in the distal part of the nephron have been found in people with Gordon’s syndrome (400).”