H2S Induces a Suspended Animation–Like State in Mice

By Eric Blackstone, Michael L. Morrison, M. Roth. Science, 2005

802 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/e2588ae06cf6b24da6f08a30ae59ba195da0f2ec

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. Rui Wang
2. P. Nagy
3. Guy C. Brown
4. S. Snyder
5. Chris E. Cooper
6. H. Eltzschig
7. C. Winterbourn
8. T. Eckle

In Physiology

1. P. Nagy
2. Rui Wang
3. Guy C. Brown
4. Lawrence T. Reiter
5. S. Snyder
6. Chris E. Cooper
7. H. Eltzschig
8. C. Winterbourn

Citations in the corpus

• Drosophila orthologues to human disease genes: an update on progress. (2008, background): “Animation state in mice can be suspended by H2S‐induced strong suppression of oxygen use (97).”
• Ischemia and reperfusion—from mechanism to translation (2011, background): “, H 2 S can induce a reversible state of hypothermia and a suspended-animation–like state in rodent”
• H2S Signals Through Protein S-Sulfhydration (2009, background): “Recent evidence indicates that hydrogen sulfide (H2S) also acts as a messenger to elicit hibernation states (2), inhibit insulin signaling (3), and regulate inflammation (4) and blood vessel caliber (5).”
• Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. (2012, background): “For example, inhalation of low level H2S rendered the mice consumed 10-fold less oxygen and reduced their basal metabolic rate (56).”
• The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance (2008, positive): “…animation-like state” in mice, that is mice were given sufficient H2S to inhibit whole body oxygen consumption (via inhibition of cytochrome oxidase) by around 90% for 6 hours, and when resuscitated where found to be undamaged and behaviourally normal (Blackstone et al. 2005; Volpato et al. 2008).”
• Redox chemistry of biological thiols (2010, background): “It induces suspended animation in mice by decreasing oxygen consumption and drastic reduction of metabolic rate [212] and increases thermotolerance and lifespan in Caenorhabditis elegans [213].”