Benefits of Modest Weight Loss in Improving Cardiovascular Risk Factors in Overweight and Obese Individuals With Type 2 Diabetes
By R. Wing, W. Lang, T. Wadden, M. Safford, W. Knowler, A. Bertoni, James O Hill, F. Brancati, A. Peters, L. Wagenknecht. Diabetes Care, 2011
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OBJECTIVE Overweight and obese individuals are encouraged to lose 5–10% of their body weight to improve cardiovascular disease (CVD) risk, but data supporting this recommendation are limited, particularly for individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS We conducted an observational analysis of participants in the Look AHEAD (Action For Health in Diabetes) study (n = 5,145, 40.5% male, 37% from ethnic/racial minorities) and examined the association between the magnitude of weight loss and changes in CVD risk factors at 1 year and the odds of meeting predefined criteria for clinically significant improvements in risk factors in individuals with type 2 diabetes. RESULTS The magnitude of weight loss at 1 year was strongly (P < 0.0001) associated with improvements in glycemia, blood pressure, tryiglycerides, and HDL cholesterol but not with LDL cholesterol (P = 0.79). Compared with weight-stable participants, those who lost 5 to <10% ([means ± SD] 7.25 ± 2.1 kg) of their body weight had increased odds of achieving a 0.5% point reduction in HbA1c (odds ratio 3.52 [95% CI 2.81–4.40]), a 5-mmHg decrease in diastolic blood pressure (1.48 [1.20–1.82]), a 5-mmHg decrease in systolic blood pressure (1.56 [1.27–1.91]), a 5 mg/dL increase in HDL cholesterol (1.69 [1.37–2.07]), and a 40 mg/dL decrease in triglycerides (2.20 [1.71–2.83]). The odds of clinically significant improvements in most risk factors were even greater in those who lost 10–15% of their body weight. CONCLUSIONS Modest weight losses of 5 to <10% were associated with significant improvements in CVD risk factors at 1 year, but larger weight losses had greater benefits.
Subfields: Endocrinology, Diabetes and Metabolism, Surgery
View Paper: https://www.semanticscholar.org/paper/e255352983f0832ba4b41a003633e20e137c2853
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Citations in the corpus
- Once-Weekly Semaglutide in Adults with Overweight or Obesity. (2021, background): “, prediabetes, hypertension, and obstructive sleep apnea).(1,20,21,27) In the semaglutide group, approximately 70% of participants achieved a weight loss of at least 10%, and approximately 50% achieved a weight loss of at least 15%.”
- The Role of Exercise and Physical Activity in Weight Loss and Maintenance (2013, background): “Clinically significant weight loss (≥5% of baseline body weight) has been shown to be more effective in reducing CV and T2DM risk factors.(4) Thus, a strong rationale exists for clinicians to advocate that overweight”
- Why Does Obesity Cause Diabetes? (2022, background): “Normally, approximately 30%of ingested glucose is taken up by skeletal muscle, of which 50% is oxidized, 35% is stored as glycogen, and about 15% undergoes non-oxidative glycolysis, which produces lactate, alanine, and pyruvate (Kelley et al., 1988; Woerle et al., 2003).”