RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts

By Sarah Geisler, J. Coller. Nature reviews. Molecular cell biology, 2013

1,393 citations recorded by the source corpus.

The increased application of transcriptome-wide profiling approaches has led to an explosion in the number of documented long non-coding RNAs (lncRNAs). While these new and enigmatic players in the complex transcriptional milieu are encoded by a significant proportion of the genome, their functions are mostly unknown. Early discoveries support a paradigm in which lncRNAs regulate transcription via chromatin modulation, but new functions are steadily emerging. Given the biochemical versatility of RNA, lncRNAs may be used for various tasks, including post-transcriptional regulation, organization of protein complexes, cell-cell signalling and allosteric regulation of proteins.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e242b24f8737dd2c7aae193b8e821351052b6d84

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation (2014, methodology): “Using our CRISPRi library design algorithm, we selected and cloned up to three sgRNAs each targeting six characterized lncRNAs (GAS5,H19,MALAT1,NEAT1, TERC, XIST) (Geisler and Coller, 2013) with good evidence of expression in K562 cells.”
Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA (2017, background): “There are many more examples of this kind of interaction [23].”
MicroRNA (miRNA) in cancer (2015, background): “…has also suggested the involvement of long noncoding RNA (IncRNA) in the development and progression of cancer [10] by exerting their regulatory functions through specific interactions with proteins, including epigenetic modifiers, transcriptional factors/co-activators, and RNP complex [11-13].”
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “Taking into consideration what has been published to date, different main groups of action for lncRNAs in accordance to Geisler and Coller (80) can be catalogued, where lncRNAs are grouped according to the level of acting on expression changes: lncRNAs acting as regulators of transcription; this tak”
UFold: fast and accurate RNA secondary structure prediction with deep learning (2020, neutral): “Aside from its conventional role as an intermediate between DNA and protein, cellular RNA consists of many other functional classes, including ribosomal RNA (rRNA), transfer RNA (tRNA), small nuclear RNA (snRNA), microRNA and other noncoding RNAs (1–4).”
Revealing protein–lncRNA interaction (2015, background): “Others function as molecular decoys, binding to specific transcription factors to prevent their association with DNA [7].”
Long Non-coding RNAs in the Cytoplasm (2016, background): “ncRNAs more than 200 nucleotides in length are called long ncRNAs (lncRNAs), which are often transcribed by RNA polymerase II [3,4].”