Defining normoxia, physoxia and hypoxia in tumours-implications for treatment response.

By S. Mckeown. British Journal of Radiology, 2014

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PhysiCell: An open source physics-based cell simulator for 3-D multicellular systems (2017, methodology): “We simulated HDS growth by placing an initial cluster of * 2300 cells in an 8 mm(3) fluid domain, with Dirichlet conditions pO2 = 38 mmHg (5% oxygen: physioxic conditions [37]) on the computational boundary.”
Role of hypoxia in cancer therapy by regulating the tumor microenvironment (2019, background): “HIFs play a central role in cellular mechanisms triggered in response to hypoxia [17, 18].”
Tumor-associated stromal cells as key contributors to the tumor microenvironment (2016, background): “Oxygen tensions above 21 % are typically considered “hyperoxic” [57].”
Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy. (2020, background): “In fact, oxygenation in tissues vary but generally average around 5% while most tumors exhibit <2% oxygen (Campillo et al., 2019; McKeown, 2014).”