Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions

By Paula Ruiz-Castillo, S. Buchwald. Chemical Reviews, 2016

2,095 citations recorded by the source corpus.

Pd-catalyzed cross-coupling reactions that form C–N bonds have become useful methods to synthesize anilines and aniline derivatives, an important class of compounds throughout chemical research. A key factor in the widespread adoption of these methods has been the continued development of reliable and versatile catalysts that function under operationally simple, user-friendly conditions. This review provides an overview of Pd-catalyzed N-arylation reactions found in both basic and applied chemical research from 2008 to the present. Selected examples of C–N cross-coupling reactions between nine classes of nitrogen-based coupling partners and (pseudo)aryl halides are described for the synthesis of heterocycles, medicinally relevant compounds, natural products, organic materials, and catalysts.

Subfields: Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/e1a8e69b79ca263bc63646f273d70bc6719c3771

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In Organic Chemistry

1. C. P. Jiménez‐Gómez
2. J. A. Cecilia

Citations in the corpus

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