The neuro-symphony of stress

By Marian Joëls, Tallie Z. Baram. Nature Reviews Neuroscience, 2009

1,510 citations recorded by the source corpus.

The impact of stress on brain function is increasingly recognized. Various substances are released in response to stress and can influence distinct neuronal circuits, but the functional advantages of having such a diversity of stress mediators remain unclear. Individual neurotransmitter, neuropeptide and steroid stress mediators have specific spatial and temporal niches, but these niches also overlap. In addition, the effects of individual mediators on neuronal function and plasticity are integrated, and emerging evidence suggests that there is crosstalk between them. Together, this results in the stress instruments producing an orchestrated 'symphony' that enables fine-tuned responses to diverse challenges.

Subfields: Behavioral Neuroscience, Endocrine and Autonomic Systems, Social Psychology

View Paper: https://www.semanticscholar.org/paper/e12874636a929936e7f1cc1edc4ab1de3ca5d62a

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Citations in the corpus

A Comprehensive Overview on Stress Neurobiology: Basic Concepts and Clinical Implications (2018, background): “Epileptogenesis is a multi-stage process that can begin early in life and may be negatively influenced by stress (Joëls, 2009), and it is now suggested that early life stress can create permanent vulnerability to the development of epilepsy (Huang, 2014).”
Neurobiological Interactions Between Stress and the Endocannabinoid System (2016, background): “…2009; Roozendaal et al, 2009), in brief, stress and glucocorticoids typically facilitate learning performances (Akirav et al, 2004; Salehi et al, 2010) and enhance memory consolidation (de Kloet et al, 1999; Joels and Baram, 2009; Oitzl and de Kloet, 1992; Roozendaal, 2000; Sandi and Rose, 1994).”
Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy (2012, background): “Stress is a familiar but imprecise term for the disruption of homeostasis that occurs following perceived or actual exposure to adverse events, and it harnesses a vast repertoire of neuromodulators that either promote or counter its effec”
Psychobiological Mechanisms Underlying the Social Buffering of the HPA Axis: A Review of Animal Models and Human Studies across Development (2013, background): “Rather, its activation is the result of a fine-tuned cascade of neural events that involve a large number of brain regions and neurotransmitters, creating a true “neuro-symphony of stress” (Joëls & Baram, 2009).”
Stress, memory and the amygdala (2009, background): “The amygdala in memory consolidation Acute stress exposure induces the activation of many different hormonal and neurotransmitter system”
The role of inflammation in epilepsy (2010, neutral): “157 The presumed mechanism of action of the therapeutic agents listed above is suppression of inflammation; how ever, other modes of action might also be involved, including direct effects on brain excitability, 158 and suppression of endogenous proconvulsant brain agents.”
Stress enhances emotional memory-related theta oscillations in the medial temporal lobe (2021, background): “The exposure to acute stress triggers the release of a cocktail 24 of hormones, peptides, and neurotransmitters, many of which exert a direct effect on neuronal activity 25 (Joëls and Baram, 2009; Kim and Diamond, 2002).”