Corticostriatal functional connectivity predicts transition to chronic back pain
By Marwan N. Baliki, B. Petre, Souraya Torbey, Kristina M Herrmann, Lejian Huang, T. Schnitzer, H. L. Fields, Vania A. Apkarian. Nature Neuroscience, 2012
973 citations recorded by the source corpus.
The mechanism of brain reorganization in pain chronification is unknown. In a longitudinal brain imaging study, subacute back pain (SBP) patients were followed over the course of 1 year. When pain persisted (SBPp, in contrast to recovering SBP and healthy controls), brain gray matter density decreased. Initially greater functional connectivity of nucleus accumbens with prefrontal cortex predicted pain persistence, implying that corticostriatal circuitry is causally involved in the transition from acute to chronic pain.
Subfields: Cardiology and Cardiovascular Medicine, Pharmacology, Physiology
View Paper: https://www.semanticscholar.org/paper/e0f0c0e09e0c3019b73990ccc31d83841c238aed
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Citations in the corpus
- Role of the Prefrontal Cortex in Pain Processing (2018, background): “Initially, greater functional connectivity of the PFC to the nucleus accumbens predicted pain persistence, implying the corticostriatal circuitry is causally involved in the transition from acute to chronic pain [40].”
- Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits. (2013, background): “In the 1-year period marking the transition to chronic pain in persisting SBP, but not in recovering SBP, the brain undergoes regional morphological changes, including decreased grey matter density in insula, S1/M1 and nucleus accumbens, and related alterations in functional connectivity, which coll”
- The Link between Depression and Chronic Pain: Neural Mechanisms in the Brain (2017, background): “Meanwhile, the effect of PFC on pain development via the nucleus accumbens has also been verified [19], thus indicating that the occurrence and development of pain and depression may be associated with some identical neuroplasticity changes.”