Targeted protein degradation: expanding the toolbox

By M. Schapira, M. Calabrese, A. Bullock, C. Crews. Nature reviews. Drug discovery, 2019

767 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/e0debf22cb71e620d39f15414542d197d4f114e8

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In Molecular Biology

1. Juri Rappsilber

Citations in the corpus

• Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses (2021, background): “in the form of proteolysis-targeting chimera-(PROTAC-) or molecular glue-type compounds [83,84].”
• Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs (2022, methodology): “” PROteolysis TArgeting Chimeras (PROTACs) are a promising therapeutic modality that utilizes the Ubiquitin-Proteasome System (UPS) to selectively induce target protein degradation (TPD) (1).”