New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?
By K. Luger, M. L. Dechassa, D. Tremethick. Nature reviews. Molecular cell biology, 2012
715 citations recorded by the source corpus.
The compaction of genomic DNA into chromatin has profound implications for the regulation of key processes such as transcription, replication and DNA repair. Nucleosomes, the repeating building blocks of chromatin, vary in the composition of their histone protein components. This is the result of the incorporation of variant histones and post-translational modifications of histone amino acid side chains. The resulting changes in nucleosome structure, stability and dynamics affect the compaction of nucleosomal arrays into higher-order structures. It is becoming clear that chromatin structures are not nearly as uniform and regular as previously assumed. This implies that chromatin structure must also be viewed in the context of specific biological functions.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/e0d3b4021afb78779ac1ee37ed70bc89ede7fdc0
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In Molecular Biology
Citations in the corpus
- Topological polymorphism of nucleosome fibers and folding of chromatin (2021, background): “This configuration is perfectly suitable for interdigitating the flipped-out nucleosome (6,76) into the neighboring array (large blue arrow in Fig.”
- The physics of epigenetics (2015, background): “The 3D structural arrangement of several arrays can finally be viewed as the chromatin tertiary structure (Luger, Dechassa, and Tremethick, 2012; Pepenella, Murphy, and Hayes, 2014); see Fig.”