Molecular Actions of PPARα in Lipid Metabolism and Inflammation.

By Nadia Bougarne, Basiel Weyers, Sofie J. Desmet, J. Deckers, D. Ray, Bart Staels, K. De Bosscher. Endocrine reviews, 2018

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Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor of clinical interest as a drug target in various metabolic disorders. PPARα also exhibits marked anti-inflammatory capacities. The first-generation PPARα agonists, the fibrates, have however been hampered by drug-drug interaction issues, statin drop-in, and ill-designed cardiovascular intervention trials. Notwithstanding, understanding the molecular mechanisms by which PPARα works will enable control of its activities as a drug target for metabolic diseases with an underlying inflammatory component. Given its role in reshaping the immune system, the full potential of this nuclear receptor subtype as a versatile drug target with high plasticity becomes increasingly clear, and a novel generation of agonists may pave the way for novel fields of applications.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e038f657c513da644e56ffe462b34f35ee51c6d8