Mathematical modeling of bioerodible, polymeric drug delivery systems.

By J. Siepmann, A. Göpferich. Advanced Drug Delivery Reviews, 2001

724 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/dffdde580476226a18a89b24e08f0eed67538f99

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In Pharmaceutical Science

Citations in the corpus

Lifetime prediction of biodegradable polymers (2017, methodology): “In an expansion of this initial work, a 3-D model was developed [39, 135-137] in which each pixel had the same volume in the total sphere, although with varying widths in the twodimensional cross-sections, and was assigned to be either polymer or drug.”
Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier (2011, background): “where Mw(t = 0) is the molecular weight of the polymer at time t = 0 and kdeg is the polymer degradation constant [74,97,98].”
Drug Release Kinetics and Transport Mechanisms of Non-degradable and Degradable Polymeric Delivery Systems (2010, background): “In addition, it would be of great significance to develop models that take into account physiological conditions, including such variables as pH, osmotic pressure, cellular tissue reactions, enzyme concentration, and so on [39].”
Polymer biodegradation: mechanisms and estimation techniques. (2008, background): “Some authors describe erosion mechanisms of polymers: surface erosion for aliphatic–aromatic copolyesters (Muller, 2006), PHB (Tsuji and Suzuyoshi, 2002) and polyanhydrides (Göpferich and Tessmar, 2002); and bulk erosion for PLA and PLGA (Siepmann and Göpferich, 2001).”
Applications of nanoparticle systems in drug delivery technology (2017, background): “The release of drug from the nanoparticle-based formulation depends on may factors including, pH, temperature, drug solubility, desorption of the surface-bound or adsorbed drug, drug diffusion through the nanoparticle matrix, nanoparticle matrix swelling and erosion, and the combination of erosion a”
The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems--a review. (2011, methodology): “It is also complementary to previous reviews covering other polymers in addition to PLGA, and focusing on mathematical modeling of drug release (Siepmann and Göpferich, 2001; Siepmann and Siepmann, 2008).”