Extended-Spectrum β-Lactamase Genes of Escherichia coli in Chicken Meat and Humans, the Netherlands
By I. Overdevest, I. Willemsen, M. Rijnsburger, A. Eustace, Li Xu, Peter Hawkey, M. Heck, P. Savelkoul, C. Vandenbroucke-Grauls, K. van der Zwaluw and 2 more. Emerging Infectious Diseases, 2011
632 citations recorded by the source corpus.
We determined the prevalence and characteristics of extended-spectrum β-lactamase (ESBL) genes of Enterobacteriaceae in retail chicken meat and humans in the Netherlands. Raw meat samples were obtained, and simultaneous cross-sectional surveys of fecal carriage were performed in 4 hospitals in the same area. Human blood cultures from these hospitals that contained ESBL genes were included. A high prevalence of ESBL genes was found in chicken meat (79.8%). Genetic analysis showed that the predominant ESBL genes in chicken meat and human rectal swab specimens were identical. These genes were also frequently found in human blood culture isolates. Typing results of Escherichia coli strains showed a high degree of similarity with strains from meat and humans. These findings suggest that the abundant presence of ESBL genes in the food chain may have a profound effect on future treatment options for a wide range of infections caused by gram-negative bacteria.
Subfields: Endocrinology, Food Science, Molecular Medicine
View Paper: https://www.semanticscholar.org/paper/dfdee017ed90eae3eb183a24bca93714da40124e
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Citations in the corpus
- Extended-spectrum β-lactamase-producing and AmpC-producing Escherichia coli from livestock and companion animals, and their putative impact on public health: a global perspective. (2012, neutral): “coli producing ESBL/ AmpC in food-producing animals, and strains relevant to human health are increasingly being isolated also from companion animals [6,7,12,24,25].”
- Escherichia coli ST131, an Intriguing Clonal Group (2014, background): “coli isolates from retail chicken meat have rarely been successful (35, 186, 190, 191, 209).”
- Antimicrobial resistance: A global emerging threat to public health systems (2017, background): “These pathogens from food-producing animals can infect humans not only via food-borne routes through the consumption of contaminated or cross-contaminated foods of animal origin (Aarestrup et al., 2007; Overdevest et al., 2011) but also by routes such as water or environmental contamination, as well”