Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma.

By S. Urba, M. Orringer, A. Turrisi, M. Iannettoni, A. Forastiere, Myla H. Strawderman. Journal of Clinical Oncology, 2001

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Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial (2018, background): “The sample size of ESCC was relatively small in most trials(5-11); there were usually no more than 80 cases of patients with ESCC receiving NCRT in each study.(5-13) Whether the results could be applied to East Asian countries such as China where the incidence of ESCC is extremely high remains to be”
A Randomized Trial Comparing Postoperative Adjuvant Chemotherapy with Cisplatin and 5-Fluorouracil Versus Preoperative Chemotherapy for Localized Advanced Squamous Cell Carcinoma of the Thoracic Esophagus (JCOG9907) (2011, background): “In Western countries, preoperative chemoradiotherapy is one of the standard treatments, but the results of the JCOG9204 study showed far better survival than that of those trials [2-4].”