SMEDWI-2 Is a PIWI-Like Protein That Regulates Planarian Stem Cells

By P. Reddien, Néstor J. Oviedo, Joya R Jennings, J. Jenkin, A. Sánchez Alvarado. Science, 2005

622 citations recorded by the source corpus.

Subfields: Global and Planetary Change, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/df5ff27d241e47d3697556b990d99db29512b9f0

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In Molecular Biology

1. Zena Werb
2. M. Egeblad
3. Andrew J. Ewald
4. Toshiaki Watanabe
5. E. Li
6. Hiroyuki Sasaki
7. Y. Matsuda
8. Pengfei Lu

Citations in the corpus

• Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy (2008, positive): “In fact, the only aspect of the Smed-PTEN loss-of-function phenotype rescued by abrogation of Smed-Akt, is the regression of the area in front of the photoreceptor – a region of the animal devoid of proliferative activity, and which is maintained exclusively by the migration of postmitotic neoblast ”
• DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. (2008, positive): “…as essential molecules for stem cell selfrenewal and maintenance in Drosophila, Caenorhabditis elegans, and certain plant species (Cox et al. 1998; Moussian et al. 1998), and a member of the family is essential for stem cell function during regeneration in planaria (Reddien et al. 2005).”