Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain

By K. Schmierer, F. Scaravilli, D. Altmann, Gareth J. Barker, David H. Miller. Annals of Neurology, 2004

789 citations recorded by the source corpus.

Subfields: Pathology and Forensic Medicine, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/df4ce668ac4356628c0ac7c363fad78270b6e382

How researchers see this paper

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In Pathology and Forensic Medicine

1. Catherine Lebel

In Radiology, Nuclear Medicine and Imaging

1. Catherine Lebel
2. Nikolaus Weiskopf
3. Sean C. L. Deoni
4. Roberto Cabeza
5. Simon W. Davis
6. David J. Madden
7. Leonard E. White
8. Nancy A. Dennis

Citations in the corpus

• Using high-resolution quantitative mapping of R1 as an index of cortical myelination (2014, positive): “T1 relaxation times are highly correlated with myelin content in unfixed spinal cord (r = 0.78, Mottershead et al., 2003), unfixed brain (r = 0.70, Schmierer et al., 2004; r = 0.77, Schmierer et al., 2008), and fixed brain (r = 0.89, Schmierer et al., 2008).”
• Characterization of Cerebral White Matter Properties Using Quantitative MRI Stains (2011, background): “There is growing evidence that MT-based MRI may be the most sensitive imaging technique capable of tracking myelin changes in patients with MS (Chen et al., 2005, 2007; Deloire-Grassin et al., 2000; Dousset et al., 1992, 1995; Schmierer et al., 2004; Trapp et al., 1998).”
• Diffusion Tensor Imaging of Post Mortem Multiple Sclerosis Brain (2006, neutral): “…correlates of several MR indices including T1 hypo-intensity (van Walderveen et al., 1998; van Waesberghe et al., 1999; Barkhof et al., 2003), T1- (Schmierer et al., 2004a) and T2-RT (Moore et al., 2000) and MT ratio (van Waesberghe et al., 1999; Barkhof et al., 2003; Schmierer et al., 2004a).”
• The Development of Brain White Matter Microstructure (2018, background): “MTR and qMT both show strong associations with myelin content in postmortem studies (Schmierer et al., 2004, 2007, 2008).”
• Multi-Parametric Neuroimaging Reproducibility: A 3T Resource Study (2010, background): “The total scan time was 4 min 12 s. Magnetization transfer (MT) imaging MT imaging is exquisitely sensitive to the macromolecular composition of tissue, and particularly in the central nervous system, alterations in the myelin content (Schmierer et al., 2004).”
• Assessing the effects of age on long white matter tracts using diffusion tensor tractography (2009, background): “Furthermore, a recent analysis of post mortem MS brain tissue has shown FA and RD–but not AD–to be significant predictors of myelin content (Schmierer et al., 2004), providing some of the most compelling support for the relationship between RD and myelin content.”
• Myelin and iron concentration in the human brain: A quantitative study of MRI contrast (2014, background): “There have been only a few quantitative attempts to find a relationship between myelin content and T1 (Bot et al., 2004; Mottershead et al., 2003; Schmierer et al., 2004), which has been reviewed recently by Laule et al.”