Targeting Malaria Virulence and Remodeling Proteins to the Host Erythrocyte

By M. Marti, R. Good, M. Rug, E. Knuepfer, A. Cowman. Science, 2004

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Plasmodium falciparum Erythrocyte Membrane Protein 1 Diversity in Seven Genomes – Divide and Conquer (2010, background): “HB20 described the pentameric motif [KR]xLx[EQD] known as the Plasmodium export element (PEXEL), which is required for protein transport to the host erythrocyte [81].”
A catalogue of the effector secretome of plant pathogenic oomycetes. (2006, background): “The RXLR motif is similar to a host-targeting signal that is required for translocation of proteins from malaria parasites (Plasmodium species) into the cytoplasm of host cells (36, 55), leading to the hypothesis that RXLR functions as a signal that mediates NBS-LRR: nucleotide binding site and leuc”
Malaria: Biology and Disease. (2016, neutral): “of proteins out of the parasite and beyond the parasitophorous vacuole membrane to numerous locations within the parasite-infected erythrocyte (Hiller et al., 2004; Marti et al., 2004; Sargeant et al., 2006) (Figure 3).”
A Systematic Map of Genetic Variation in Plasmodium falciparum (2006, positive): “A conserved pentameric sequence (Pexel motif) [41] and an 11-amino acid signal (host-targeting [HT] motif) [42], which are frequently found in parasite proteins that are targeted to the red blood cell, have been identified, and such proteins have been proposed as candidates for proteins interacting ”