Angiogenic and cell survival functions of Vascular Endothelial Growth Factor (VEGF)

By A. Byrne, D. Bouchier‐Hayes, J. Harmey. Journal of Cellular and Molecular Medicine, 2005

734 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/df197c84ce77e1c182909ac5b826639059522e94

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In Molecular Biology

1. Huanhuan Chen
2. Li-li Zheng
3. Zhenling Liu
4. Li-Ping Sun
5. Lei Shi

Citations in the corpus

• Angiogenic signaling pathways and anti-angiogenic therapy for cancer (2023, background): “VEGFR-2 (known as KDR or FLK-1) is a 210–230 kDa transmembrane glycoprotein, generally expressed by vascular endothelial cells, lymphatic endothelial cells, endothelial progenitor cells, megakaryocytes, and hematopoietic stem cells.(100) Under the mediation of VEGF-A, VEGFR-2 undergoes autophosphory”
• Targeting PI3K/Akt signal transduction for cancer therapy (2021, background): “Therefore, VEGFRs vitally stabilize neovascularization and promote cell survival and migration.(46) Similarly, VEGF forms VEGF/ VEGFR-2 dimers, which activate the PI3K/Akt pathway to mediate tumor metastasis and angiogenesis.”