RNA-mediated epigenetic regulation of gene expression

By D. Holoch, D. Moazed. Nature reviews genetics, 2015

961 citations recorded by the source corpus.

Diverse classes of RNA, ranging from small to long non-coding RNAs, have emerged as key regulators of gene expression, genome stability and defence against foreign genetic elements. Small RNAs modify chromatin structure and silence transcription by guiding Argonaute-containing complexes to complementary nascent RNA scaffolds and then mediating the recruitment of histone and DNA methyltransferases. In addition, recent advances suggest that chromatin-associated long non-coding RNA scaffolds also recruit chromatin-modifying complexes independently of small RNAs. These co-transcriptional silencing mechanisms form powerful RNA surveillance systems that detect and silence inappropriate transcription events, and provide a memory of these events via self-reinforcing epigenetic loops.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/de9fe33b907f3417c8d4fda727f5bb90aa2e0a5a

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Citations in the corpus

• A proteome-wide fission yeast interactome reveals network evolution principles from yeasts to human (2016, background): “Comparative Network Analyses Reveal Species-Specific Conservation of Interactions High-quality protein interactome networks have previously been reported in budding yeast (Yu et al., 2008) and human (Rolland et al., 2014).”
• The delivery of therapeutic oligonucleotides (2016, background): “As mentioned above, miRNA can also regulate transcription within the nucleus by utilizing other forms of RISC complexes (27).”