The Year 2000 Integrin Model

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INTEGRIN LIGANDS (2006, background): “…equally to this article ‡Author for correspondence (e-mail: martin.humphries@manchester.ac.uk) Journal of Cell Science 119, 3901-3903 Published by The Company of Biologists 2006 doi:10.1242/jcs.03098 Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002).”
Demonstration of catch bonds between an integrin and its ligand (2009, background): “Activation can also be triggered by divalent cations and by binding of activating mAbs to cell surface or purified integrins (Humphries, 2000).”
Integrin structure, activation, and interactions. (2011, background): “Conversely, many extracellular matrix (ECM) and cell surface adhesion proteins bind to multiple integrin receptors (Humphries 2000; Plow et al. 2000; van der Flier and Sonnenberg 2001).”
Transmembrane signal transduction of the αIIbβ3 integrin (2002, methodology): “In inside-out signaling, the binding of certain factors to the intracellular domain of the integrin leads to a conformational change that alters the relative orientation of the two monomers to each other (Hantgan et al. 1999; Emsley et al. 2000; Humphries 2000; Liddington and Bankston 2000).”