Erectile dysfunction.

By A. L. A S T A I, R. J. J. W. O O D, E. Rectile, D. Ysfunction, T. Om, F. L. Ue, Penile Flaccidity. Harvard men's health watch, 2006

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A side effect resource to capture phenotypic effects of drugs (2010, background): “The occurrence of erectile dysfunction for non-selective b -blockers has been explained with their action on a - adrenergic receptors in penile tissue (Lue, 2000), thus providing an example of closely related off-targets in different tissues.”
Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation. (2010, unknown): “Inhibition of PDE5 results in increased arterial blood flow leading to smooth muscle relaxation, vasodilatation and penile erection (30).”
Diabetic Neuropathies: Update on Definitions, Diagnostic Criteria, Estimation of Severity, and Treatments (2010, background): “Neuropathy is one of the leading causes of ED, along with glycation of elastic fibers, peripheral vasculopathy, endothelial dysfunction, psychological factors, drugs, and hormonal changes (47).”
European Guidelines on Cardiovascular Disease Prevention in Clinical Practice (Version 2012) (2012, unknown): “It may result from psychological, neurological, hormonal, arterial, or cavernosal impairment or from a combination of these factors.(179,181) ED has a high prevalence in individuals with multiple cardiovascular risk factors and in individuals with CVD.”