Microfluidic devices for bioapplications.

By Leslie Y. Yeo, Hsueh-Chia Chang, P. Chan, James R. Friend. Small, 2011

577 citations recorded by the source corpus.

Harnessing the ability to precisely and reproducibly actuate fluids and manipulate bioparticles such as DNA, cells, and molecules at the microscale, microfluidics is a powerful tool that is currently revolutionizing chemical and biological analysis by replicating laboratory bench-top technology on a miniature chip-scale device, thus allowing assays to be carried out at a fraction of the time and cost while affording portability and field-use capability. Emerging from a decade of research and development in microfluidic technology are a wide range of promising laboratory and consumer biotechnological applications from microscale genetic and proteomic analysis kits, cell culture and manipulation platforms, biosensors, and pathogen detection systems to point-of-care diagnostic devices, high-throughput combinatorial drug screening platforms, schemes for targeted drug delivery and advanced therapeutics, and novel biomaterials synthesis for tissue engineering. The developments associated with these technological advances along with their respective applications to date are reviewed from a broad perspective and possible future directions that could arise from the current state of the art are discussed.

Subfields: Biomedical Engineering

View Paper: https://www.semanticscholar.org/paper/ddecc0d41996e9b38c440135b92222eff6fb7ebf

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In Biomedical Engineering

Citations in the corpus

Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices. (2015, background): “Microfluidic systems have the potential to integrate cell culture with the aforementioned analytical chemistry on a single device, thereby increasing reproducibility (Yeo et al., 2011; Rubakhin et al., 2011).”
Surface Acoustic Wave Microfluidics (2014, background): “…is confined and directed toward the drop’s free surface with sufficient inertia to overcome the capillary stress and hence deform the drop interface, it is possible to extrude a thin liquid jet that emanates from the free surface of the drop; this was first illustrated by Shiokawa et al. (1990).”
Emerging Technologies for Next-Generation Point-of-Care Testing. (2015, unknown): “Microfluidic cell trapping and sorting capabilities are 100 cell/s, but still significantly lower than flow cytometry [16].”