Precise Long-Range Synchronization of Activity and Silence in Neocortical Neurons during Slow-Wave Sleep
By Maxim Volgushev, Sylvain Chauvette, M. Mukovski, Igor Timofeev. Journal of Neuroscience, 2006
278 citations recorded by the source corpus.
Slow-wave sleep is characterized by alternating periods of activity and silence in corticothalamic networks. Both activity and silence are stable network states, but the mechanisms of their alternation remain unknown. We show, using simultaneous multisite intracellular recordings in cats, that slow rhythm involves all neocortical neurons and that both activity and silence started almost synchronously in cells located up to 12 mm apart. Activity appeared predominantly at the area 5/7 border and spread in both anterior and posterior directions. The activity started earlier in fast-spiking cells and intrinsically bursting cells than in regular-spiking neurons. These results provide direct evidence for two mechanisms of active state generation: spread of activity from a local focus and synchronization of weaker activity, originating at multiple locations. Surprisingly, onsets of silent states were synchronized even more precisely than the onsets of activity, showing no latency bias for location or cell type. This most intriguing finding exposes a major gap in understanding the nature of state alternation. We suggest that it is the synchronous termination of activity and occurrence of silent states of the neuronal network that makes the EEG picture during slow-wave sleep so characteristic. Synchronous onset of silence in distant neurons cannot rely exclusively on properties of individual cells and synapses, such as adaptation of neuronal firing or synaptic depression; instead, it implies the existence of a network mechanism. Revealing this yet unknown large-scale mechanism, which switches network activity to silence, will aid our understanding of the origin of brain rhythms in normal function and pathology.
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View Paper: https://www.semanticscholar.org/paper/ddb2c6bc05fd19103057a214f18f97a5a6617f33
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Citations in the corpus
- Regional slow waves and spindles in human sleep. (2011, unknown): “…is remarkably synchronous when examined in brain slices (Sanchez-Vives and McCormick, 2000), in animals under anesthesia (Steriade et al., 1993b,1993c), and in natural sleep, as shown by intracellular recordings of up to four neurons simultaneously (Chauvette et al., 2010; Volgushev et al., 2006).”
- Spatiotemporal dynamics of cortical sensorimotor integration in behaving mice. (2007, background): “Typically activity propagated as waves of depolarization reflecting UP states (Steriade et al., 1993; Cowan and Wilson, 1994; Petersen et al., 2003b; Cossart et al., 2003; Shu et al., 2003; Volgushev et al., 2006) and often very large fractions of sensorimotor cortex were synchronously depolarized.”
- Thalamocortical oscillations (2006, background): “Recent studies suggest that the onsets of silent states are synchronized even better than the onsets of activity, and showed no latency bias for any location or cell type (Volgushev et al., 2006).”
- Synaptic Mechanisms of Memory Consolidation during Sleep Slow Oscillations (2016, methodology): “During slow oscillations, the transition from a Down to Up state of oscillations occurs in a form of traveling waves (Massimini et al., 2004; Volgushev et al., 2006), possibly initiated at many independent network locations.”