The Role of Mitochondria in Apoptosis
By Chunxin Wang, R. Youle. Annual Review of Genetics, 2009
1,273 citations recorded by the source corpus.
Mitochondria play key roles in activating apoptosis in mammalian cells. Bcl-2 family members regulate the release of proteins from the space between the mitochondrial inner and outer membrane that, once in the cytosol, activate caspase proteases that dismantle cells and signal efficient phagocytosis of cell corpses. Here we review the extensive literature on proteins released from the intermembrane space and consider genetic evidence for and against their roles in apoptosis activation. We also compare and contrast apoptosis pathways in Caenorhabditis elegans, Drosophila melanogaster, and mammals that indicate major mysteries remaining to be solved.
Subfields: Epidemiology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/dd21d6c45224d96ec262d1bed6e0608fc33069b4
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In Molecular Biology
Citations in the corpus
- Mitochondrial markers for identification and phylogenetic studies in insects - A Review (2014, background): “Mitochondria - the powerhouse of a cell plays a crucial role in respiration, genetic illness, aging and self-destruction of a cell [1-4].”
- Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. (2012, neutral): “The mitochondrial pathway is triggered by the proapoptotic members of the Bcl-2 family of proteins that render the outer membrane of mitochondria permeable to factors normally located within the intermembrane space, in particular cytochrome c and Smac/ Diablo (Wang and Youle, 2009).”