Wireless smart contact lens for diabetic diagnosis and therapy
By Do Hee Keum, Su-Kyoung Kim, Jahyun Koo, Geon-Hui Lee, Cheonhoo Jeon, J. Mok, Beomho Mun, Keon Jae Lee, E. Kamrani, C. Joo and 6 more. Science Advances, 2020
385 citations recorded by the source corpus.
We demonstrate smart contact lenses for noninvasive and continuous diabetic diagnosis and diabetic retinopathy therapy. A smart contact lens can be used as an excellent interface between the human body and an electronic device for wearable healthcare applications. Despite wide investigations of smart contact lenses for diagnostic applications, there has been no report on electrically controlled drug delivery in combination with real-time biometric analysis. Here, we developed smart contact lenses for both continuous glucose monitoring and treatment of diabetic retinopathy. The smart contact lens device, built on a biocompatible polymer, contains ultrathin, flexible electrical circuits and a microcontroller chip for real-time electrochemical biosensing, on-demand controlled drug delivery, wireless power management, and data communication. In diabetic rabbit models, we could measure tear glucose levels to be validated by the conventional invasive blood glucose tests and trigger drugs to be released from reservoirs for treating diabetic retinopathy. Together, we successfully demonstrated the feasibility of smart contact lenses for noninvasive and continuous diabetic diagnosis and diabetic retinopathy therapy.
Subfields: Biomedical Engineering, Public Health, Environmental and Occupational Health, Human-Computer Interaction
View Paper: https://www.semanticscholar.org/paper/dce2c7cbf59b005b6fd65d1336b2e16957b724e3
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In Biomedical Engineering
Citations in the corpus
- The Emergence of AI-Based Wearable Sensors for Digital Health Technology: A Review (2023, background): “In this regard, Keum et al. [219] used a smart contact lens with an electrochemical biosensor to continuously monitor glucose levels in tears and, thus, perform diabetic diagnosis and diabetic retinopathy therapy.”