SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology

By F. Veras, M. Pontelli, C. Silva, J. Toller-Kawahisa, M. D. de Lima, D. Nascimento, A. Schneider, Diego B. Caetité, L. Tavares, I. Paiva and 36 more. Journal of Experimental Medicine, 2020

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The knowledge of COVID-19 pathophysiology is pivotal for the discovery of effective treatments. Here, we described that SARS-CoV-2 triggers the release of ACE2-depended neutrophil extracellular traps (NETs) that mediate lung pathology, supporting the use of NETs inhibitors for COVID-19 treatment.

Subfields: Immunology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/dcb50082443670e6b5ab47d31fab792e6b1a1ed3