Circular RNAs Act as miRNA Sponges.

By Amaresh Chandra Panda. Advances in Experimental Medicine and Biology, 2018

938 citations recorded by the source corpus.

Majority of RNAs expressed in animal cells lack protein-coding ability. Unlike other cellular RNAs, circular (circ)RNAs include a large family of noncoding (nc)RNAs that lack the 5' or 3' ends. The improvements in high-throughput RNA sequencing and novel bioinformatics tools have led to the identification of thousands of circRNAs in various organisms. CircRNAs can regulate gene expression by influencing the transcription, the mRNA turnover, and translation by sponging RNA-binding proteins and microRNAs. Given the broad impact of circRNA on miRNA activity, there is huge interest in understanding the impact of miRNA sponging by circRNA on gene regulation. In this review, we summarize our current knowledge of the miRNA-circRNA interaction and mechanisms that influence gene expression.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/dca324c5f5f73e8d2febe48411b47964131d10b8

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1. Deshen Wang
2. Ze-Rong Cai
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4. M. Correia de Sousa
5. Weiyun Zhou
6. Jia Liu
7. M. Gjorgjieva
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Citations in the corpus

• Deciphering miRNAs’ Action through miRNA Editing (2019, background): “Competing endogenous RNAs, including pseudogenes, circular RNAs and lncRNAs, play a major role in the regulation of miRNA activity by acting as natural miRNA sponges or decoys [75].”
• Circular RNA: metabolism, functions and interactions with proteins (2020, background): “Plenty of studies have confirmed that circRNAs exert biological functions by acting as ceRNAs or miR sponges [73, 74].”